Technology

LarmorBio revolutionizes magnetic resonance (MR) technology by unlocking molecular-level diagnostics. Our microscale MR technology measures unique properties associated with the redox state in the blood microenvironment, offering a rapid and cost-effective method to assess oxidative stress and chronic disease mechanisms.

Microscale Magnetic Resonance

Like rust corroding metal, oxidative stress occurs when free radicals overwhelm the body's natural defenses. This cellular damage is a critical factor in major chronic conditions, including diabetes, cardiovascular disease, kidney disease, pregnancy complications, and Alzheimer's.

Oxidative Stress and Chronic Disease

See our technology at work

Extremely simple and low-cost testing process provides previously unavailable biological information.

Current Applications Under Development

Diabetes

38 million Americans have diabetes, and the number is rising. Research shows that oxidative stress, alongside A1C testing, could offer a better understanding of diabetes progression and related complications. Studies suggest oxidative stress may provide earlier insights into the disease’s impact than A1C alone.

Cardiac Reperfusion Injury

With 2 million major cardiac surgeries occurring annually in the U.S., cardiac reperfusion injury emerges as a major post-surgery complication. LarmorBio partners with a pharmaceutical company to develop early warning systems and treatments to improve outcomes.

GLP-1 Response

1 in 13 adults in the U.S. are taking GLP-1 with the number expanding rapidly. LarmorBio collaborates with leading pharmaceutical companies to explore how oxidative stress influences the effectiveness of GLP-1 drugs. These drugs are known to reduce oxidative stress, offering a unique perspective on patient response.

Pregnancy Complications

Almost 2 in 10 pregnancies have a major complication. LarmorBio studies show that oxidative stress increases throughout pregnancy. We investigate links between high oxidative stress and pregnancy complications like preeclampsia and gestational diabetes, which may benefit from early intervention.

Peer Reviewed Publications

To date, LarmorBio’s technology has been highlighted in 12 major peer reviewed publications with a rapidly growing body of scientific evidence supporting the applicability of the technology to support both life science research and in vitro diagnostic detection of major disease.

[1] W. K. Peng, L. Chen, B. O. Boehm, J. Han, and T. P. Loh, “Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system,” NPJ Aging Mech Dis, vol. 6, no. 1, p. 11, Oct. 2020, doi: 10.1038/s41514-020-00049-0. https://pubmed.ncbi.nlm.nih.gov/33083002/

[2] W. K. Peng, T. T. Ng, and T. P. Loh, “Machine learning assistive rapid, label-free molecular phenotyping of blood with two-dimensional NMR correlational spectroscopy,” Commun Biol, vol. 3, no. 1, 2020, doi: 10.1038/s42003-020-01262-z. https://pubmed.ncbi.nlm.nih.gov/32985608/

[3] S. S. Thamarath, A. Xiong, P. H. Lin, P. R. Preiser, and J. Han, “Enhancing the sensitivity of micro magnetic resonance relaxometry detection of low parasitemia Plasmodium falciparum in human blood,” Sci Rep, vol. 9, no. 1, Dec. 2019, doi: 10.1038/s41598-019-38805-2. https://pubmed.ncbi.nlm.nih.gov/30796262/

[4] S. S. Thamarath et al., “Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry,” Stem Cells Transl Med, vol. 12, no. 5, pp. 266–280, May 2023, doi: 10.1093/stcltm/szad014. https://pubmed.ncbi.nlm.nih.gov/36988042/

[5] S. Y. Ng et al., “Hydrogen Sulfide Sensitizes Acinetobacter baumannii to Killing by Antibiotics,” Front Microbiol, vol. 11, Aug. 2020, doi: 10.3389/fmicb.2020.01875. https://pubmed.ncbi.nlm.nih.gov/32849459/

[6] W. K. Peng et al., “Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis,” Nat Med, vol. 20, no. 9, 2014, doi: 10.1038/nm.3622. https://pubmed.ncbi.nlm.nih.gov/25173428/

[7] W. K. Peng, “Clustering Nuclear Magnetic Resonance: Machine learning assistive rapid two-dimensional relaxometry mapping,” Engineering Reports, vol. 3, no. 10, 2021, doi: 10.1002/eng2.12383. https://onlinelibrary.wiley.com/doi/full/10.1002/eng2.12383

[8] W. K. Peng, L. Chen, and J. Han, “Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis,” Review of Scientific Instruments, vol. 83, no. 9. 2012. doi: 10.1063/1.4754296. https://pubmed.ncbi.nlm.nih.gov/23020427/

[9] Alves, A. T. et al. 12380 Point Of Care Microscale Magnetic Resonance (µNMR) Effectively Monitors Mitigation Of Oxidative Stress By GLP-1 Treatment In A Preclinical Model Of Diabetic Nephropathy. Journal of the Endocrine Society 8, bvae163.882 (2024). https://doi.org/10.1210/jendso/bvae163.882

[10] Alves, A. T. et al. 12362 Pathophysiology From Oxidative Stress Effectively Monitored In A Pre-clinical Model Of Type 2 Diabetes (T2D) With Point-of-care Microscale Magnetic Resonance (µNMR). Journal of the Endocrine Society 8, bvae163.877 (2024). https://doi.org/10.1210/jendso/bvae163.877

[11] He, F., Liu, J., Huang, Y., Chen, L., Rizi, E. P., Ke, Z., Ke, L., Loh, T. P., Niu, M., & Peng, W. K. (2024). Nutritional load in post-prandial oxidative stress and the pathogeneses of diabetes mellitus. Npj Science of Food, 8(1). https://doi.org/10.1038/s41538-024-00282-x

[12] Tee, C.A., Roxby, D.N., Othman, R. et al. Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair. Stem Cell Res Ther 15, 308 (2024). https://doi.org/10.1186/s13287-024-03923-w